fenbendazole is a broad-spectrum benzimidazole anthelmintic used against gastrointestinal parasites such as giardia, roundworms, hookworms, whipworms, and the tapeworm genus Taenia. It is absorbed into the bloodstream and converted to its active metabolite, oxifendazole.
Indian scientists have found that this drug, which is used in veterinary medicine, may also be useful against cancers. It kills cancer cells by causing them to enter the oxidative stress-reactive phase.
It is a broad-spectrum anti-parasitic drug
Fenbendazole is a broad-spectrum benzimidazole anthelmintic that was originally developed to treat parasitic worms in animals. It is effective against giardia, roundworms, hookworms, whipworms, and the tapeworm genus Taenia. It also kills pinworms and aelurostrongylus in freshwater fish tanks. It can be administered to cats, dogs, rabbits, most reptiles, and birds.
Scientists have found that fenbendazole can suppress the growth of cancer cells and inhibit their metabolism. It does this by causing moderate microtubule disruption, stabilizing p53, and interfering with glucose intake in the cancer cell. This leads to the preferential death of cancer cells both in vitro and in vivo.
The drug is a promising cancer treatment because it can cause the death of cancerous cells without damaging healthy ones. However, it’s important to note that there’s no evidence that fenbendazole can cure cancer in humans. It hasn’t been tested in clinical trials to prove its effectiveness or safety.
It is a potent anti-cancer agent
Fenbendazole is an established antiparasitic medication used to treat ascarids, whipworms, hookworms, and a single species of tapeworm in humans and animals. It has also recently been repurposed as an anti-cancer agent. There are a number of case studies in which patients have successfully treated their cancer using this medication.
The drug acts by inhibiting the polymerization of tubulin, which makes up microtubules. These are essential for cell growth and forming the cytoskeleton. Several cytotoxic drugs act by targeting microtubules.
A study found that fenbendazole was able to prevent tumor growth and x-ray radiation-induced lung metastasis in mice. Moreover, the drug was able to decrease x-ray-induced lung metastases by preventing the uptake of glucose in cancer cells.
The authors attributed this effect to the fact that fenbendazole impedes GLUT4 glucose uptake and starves cancer cells. It also triggers ferroptosis in cancer cells by reducing expression of GPX4 and SLC7A11. These results suggest that fenbendazole might have an anti-cancer potential.
It is safe
Fenbendazole is an anthelmintic drug used to treat gastrointestinal parasites in animals. It is usually administered orally and is well tolerated. A recent study showed that ingesting fenbendazole at doses of up to 500 mg per person for ten days did not cause any serious side effects. The same study indicated that a single dose of fenbendazole up to 2000 mg per person was also well tolerated.
The pharmacology of fenbendazole is limited and the results in humans must be verified by extensive clinical trials. However, there is evidence of anti-cancer activity in animal models and a case report that describes the success of a patient who used fenbendazole as part of a cancer treatment protocol.
The drug is available as granules or liquid suspension and can be given by mouth. The dosage must be carefully measured, especially for liquid forms. In some cases, your veterinarian may prescribe a compounded version of the medication if there is a reason that it cannot be administered as an FDA-approved medication. This is usually because your pet has difficulty taking pills in capsule form or the dosage strength is not commercially available.
It is more effective than mebendazole
Fenbendazole (marketed as Safe-Guard or Panacur) is a broad-spectrum benzimidazole anthelmintic that has been used for gastrointestinal parasites such as hookworms, whipworms, pinworms, the tapeworm genus Taenia (except for Dipylidium caninum, a common dog tapeworm), and roundworms. It also has anticancer properties and was recently shown to suppress tumor growth in mice.
The results were consistent with those of a previous study that found that fenbendazole inhibits cellular proliferation by inducing lipid peroxidation and ferroptosis. This mechanism involves the inhibition of cysteine uptake by SLC7A11 and the reduction in the expression of GPX4 by fenbendazole.
Previous studies have shown that fenbendazole is effective against the opportunistic fungus Cryptococcus neoformans, which may cause meningitis in some people. It also has been demonstrated to be more effective than mebendazole in the treatment of giardiasis. It is also more effective against the protozoan disease echinostome visceral larva migrans, which is caused by Giardia lamblia.fenbendazole for humans