Fenbendazole is a broad-spectrum antiparasitic medication. It has been found to be an effective treatment for various conditions. Its effectiveness is due to the fact that it partially alters microtubule networks and induces cell death.

The toxicity of 2- and 24-h treatments with fenbendazole to aerobic EMT6 cells was examined using a colony formation assay. Survivals were measured as yield-corrected surviving fractions.

Antiparasitic

Fenbendazole is a common anthelmintic that has been used to treat parasites in animals. It has also been reported to have anticancer properties. It works by binding to the tubulin microtubules and disrupting their stability. It also affects the cellular metabolism, which can help kill cancer cells and prevent them from multiplying.

In cell culture experiments, fenbendazole was not toxic to aerobic EMT6 monolayer cultures even when treated with doses that approached the limit of the drug’s solubility. Furthermore, 2-h treatments of fenbendazole did not significantly decrease the number of cells in the cultures or their clonogenicity.

However, the safety of long exposure to fenbendazole has not been scientifically studied. Despite this, many patients choose to take the drug on their own, as they are unwilling to wait for the lengthy bureaucratic process of waiting for scientific data. These individuals are at risk of suffering from serious side effects if they follow a protocol that is not safe for them.

Anti-cancer

Several studies have found that the benzimidazole family of drugs has powerful anti-cancer effects. These effects are primarily due to the drug’s ability to interfere with cancer cells’ glucose intake. Glucose is essential for cancer cells to grow and proliferate. Consequently, the interference with glucose starves cancer cells and causes them to die.

Fenbendazole has been found to be an effective treatment for colorectal cancer. It has been shown to inhibit the growth of tumors in mice by interfering with their glucose uptake and promoting apoptosis. It has also been shown to cause G2/M phase arrest and increased p21 expression in cancer cells.

While fenbendazole is an effective anthelmintic, it has not been shown to be safe for human consumption for long periods of time. However, many people choose to take it on their own, as it is readily available and inexpensive. They may have heard about the anti-cancer effects of fenbendazole from online sources or their doctors.

Anti-hyperglycemic

The benzimidazole anthelmintic fenbendazole can be used in humans to treat various parasitic infections. However, the drug has not been extensively studied for long-term use. It may affect immunity for prolonged periods of time, which could lead to serious side effects. This risk is especially significant for patients with autoimmune disorders or compromised immune systems.

Nevertheless, fenbendazole has been shown to inhibit glucose uptake by cancer cells and inhibit tumor growth in animal models. In addition, it has been found to stabilize WT p53, provide moderate microtubule disruption, and target cell cycle arrest.

In one study, hepatocellular carcinoma (H4IIE) cells were treated with fenbendazole and monitored for their growth rate. Results showed that the drug reduced H4IIE cell viability under both hypoxic and normoxic conditions. Furthermore, apoptosis-associated changes were also observed in FZ-treated H4IIE cells. These findings suggest that hepatocellular carcinoma cells are sensitive to fenbendazole and that this compound could be an effective antitumor agent.

Anti-tumour

Fenbendazole is a benzimidazole anti-parasitic drug that has been shown to have significant in vitro and in vivo (animal) antitumour effects. It inhibits the formation of microtubules, which helps cancer cells to grow and divide. It also blocks their ability to take up glucose for energy. It can also induce apoptosis and stop cell growth.

Researchers tested the effectiveness of fenbendazole against a variety of tumours in mice. They fed the drugs to the animals every other day for 12 days, and found that there was a significant reduction in tumor size and weight. The animals that received the drug also showed fewer spontaneous lung metastases than those in control groups.

Recently, a Canadian veterinarian was reprimanded for posting videos on TikTok that promoted fenbendazole as a cure for cancer. The vet’s claims were based on unlicensed research. The researcher cited the unlicensed video as an example of how veterinarians can mislead patients by promoting alternative therapies.fenbendazole for humans